Ph. D. Sun Yat-sen University (Neuroendocrinology)
Post-doc (1998-2000): Chonnam National University, Hormone Research Center (Molecular Endocrinology)
Post-doc (2000-2004): Baylor College of Medicine (Molecular and Cell Biology)
Research in this laboratory is focused on several related areas centered on nuclear receptor regulation of chronic liver diseases: 1) transcriptional and translational regulation of non-coding RNA (microRNA and lncRNA) in bile acid metabolism and cholestatic liver fibrosis; 2) nutrient mediated mTOR and metabolic signaling in the epigenetic control of liver cancer; 3) circadian clock control of ER stress signaling and homocysteine metabolism in alcoholic fatty liver. Our approach makes full use of system biology, molecular biology, biochemistry, and genome wide high throughput transcriptomics (RNA-seq) and metabolomics (GC-MS). Both in vitro cell culture and in vivo single and double knockout mouse models are employed for our studies.